Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | CSF1R | P07333 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789092 | 0.81 | KDR (0.75) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL4789091 | 0.81 | KDR (0.75) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL4934488 | 0.78 | KDR (0.73) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL4934493 | 0.78 | KDR (0.73) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL4884843 | 0.78 | KDR (0.70) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL4884833 | 0.78 | KDR (0.70) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL4817673 | 0.77 | SMN1; SMN2 (0.56) | PDGFRBFGFR1LMNAALDH1A1MEN1 | |
| SCHEMBL4750921 | 0.77 | ALDH1A1 (0.54) | LMNAALDH1A1MEN1HTTKMT2A | |
| SCHEMBL1044420 | 0.75 | KDR (0.59) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL4813941 | 0.72 | KDR (0.78) | KDRPDGFRBPRKAA1PRKAA2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008145398-A1 | 4-ARYLPYRROLE SUBSTITUTED 2-INDOLINE DERIVATIVES ACTIVE AS PROTEIN KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2008-12-04 | — | — | WO | disclosed |