Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.68 |
| ▸ | KDR | P35968 | 3/20 | 0.62 |
| ▸ | CSF1R | P07333 | 4/20 | 0.52 |
| ▸ | KIT | P10721 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 11/20 | 0.49 |
| ▸ | RAF1 | P04049 | 4/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789178 | 0.94 | LCK (0.58) | LCKMAPK14KDRCSF1RKIT | |
| SCHEMBL4789248 | 0.93 | LCK (0.57) | LCKMAPK14KDRCSF1RKIT | |
| SCHEMBL4789582 | 0.93 | LCK (0.57) | LCKMAPK14KDRCSF1RKIT | |
| SCHEMBL4789238 | 0.92 | LCK (0.58) | LCKMAPK14KDRSRCTYK2 | |
| SCHEMBL4789349 | 0.89 | LCK (0.52) | LCKMAPK14KDRJAK3BRAF | |
| SCHEMBL4787608 | 0.87 | CSF1R (0.57) | LCKMAPK14KDRCSF1RKIT | |
| SCHEMBL4788653 | 0.86 | CSF1R (0.55) | LCKMAPK14KDRCSF1RKIT | |
| SCHEMBL4790220 | 0.86 | LCK (0.62) | LCKMAPK14KDRCSF1RKIT | |
| SCHEMBL4789176 | 0.86 | LCK (0.50) | LCKMAPK14KDRCSF1RKIT | |
| SCHEMBL4788545 | 0.85 | CSF1R (0.51) | LCKMAPK14KDRCSF1RSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |