Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 8/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | PTGES | O14684 | 2/20 | 0.49 |
| ▸ | BRAF | P15056 | 4/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789346 | 0.93 | LCK (0.49) | LCKMAPK14KDRPTGESBRAF | |
| SCHEMBL4789239 | 0.89 | LCK (0.68) | LCKMAPK14KDRBRAFJAK3 | |
| SCHEMBL4789238 | 0.87 | LCK (0.58) | LCKMAPK14KDRJAK3 | |
| SCHEMBL4788874 | 0.84 | KMT2A (0.43) | LCKMAPK14KDRPTGESBRAF | |
| SCHEMBL4788647 | 0.83 | LCK (0.46) | LCKMAPK14KDRBRAFKMT2A | |
| SCHEMBL4789178 | 0.82 | LCK (0.58) | LCKMAPK14KDRBRAFDDR1 | |
| SCHEMBL4789582 | 0.82 | LCK (0.57) | LCKMAPK14KDRBRAFDDR1 | |
| SCHEMBL4789248 | 0.82 | LCK (0.57) | LCKMAPK14KDRBRAFEGFR | |
| SCHEMBL4789176 | 0.81 | LCK (0.50) | LCKMAPK14KDRJAK3DDR1 | |
| SCHEMBL4789243 | 0.80 | LCK (0.49) | LCKMAPK14KDRBRAFJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |