Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | ARAF | P10398 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14027871 | 0.87 | JAK1 (0.42) | BRAFJAK2JAK1TYK2PIK3CA | |
| SCHEMBL4863399 | 0.81 | AXL (0.42) | AXLPRKCIRXFP1BRAFLMNA | |
| SCHEMBL14026833 | 0.80 | BRAF (0.42) | AXLPRKCIRXFP1BRAFJAK2 | |
| SCHEMBL4790006 | 0.77 | RAF1 (0.51) | RXFP1BRAFRAF1 | |
| SCHEMBL14026832 | 0.76 | ABL1 (0.51) | BRAFPIK3CAMTOR | |
| SCHEMBL22457384 | 0.76 | MAPK14 (0.61) | BRAFRAF1 | |
| SCHEMBL4790008 | 0.76 | BRAF (0.62) | BRAFRAF1 | |
| SCHEMBL12876546 | 0.75 | AXL (0.55) | AXLPRKCIJAK2JAK1TYK2 | |
| SCHEMBL29378769 | 0.75 | AXL (0.55) | AXLPRKCIJAK2JAK1TYK2 | |
| SCHEMBL12875920 | 0.75 | AXL (0.51) | AXLPRKCIJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |