Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | MTOR | P42345 | 3/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 4/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15860020 | 0.81 | CYP1A2 (0.41) | ABL1BRAFEGFRKITCYP1A2 | |
| SCHEMBL14026831 | 0.79 | BRAF (0.52) | ABL1BRAFEGFRPIK3CAMTOR | |
| SCHEMBL1367703 | 0.76 | PIK3CA (0.60) | ABL1BRAFPIK3CAMTORKIT | |
| SCHEMBL14027871 | 0.76 | JAK1 (0.42) | BRAFPIK3CAMTOR | |
| SCHEMBL4789344 | 0.76 | AXL (0.48) | BRAFPIK3CAMTOR | |
| SCHEMBL4787038 | 0.76 | BRAF (0.74) | ABL1BRAFEGFRMAPK14KIT | |
| SCHEMBL16621418 | 0.76 | HSF1 (0.67) | ABL1BRAFEGFRMAPK11MAPK14 | |
| SCHEMBL4787030 | 0.76 | BRAF (0.61) | ABL1BRAFEGFRMAPK14KIT | |
| SCHEMBL4867903 | 0.75 | BRAF (0.53) | ABL1BRAFEGFRPIK3CAMTOR | |
| SCHEMBL13808678 | 0.75 | RIPK1 (0.55) | PIK3CARIPK1KITCDK8NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |