Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.48 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554438 | 0.83 | HDAC1 (0.60) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL3628048 | 0.72 | HDAC1 (0.51) | HDAC1HDAC2 | |
| SCHEMBL5226034 | 0.70 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL8401704 | 0.69 | HDAC1 (0.89) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL3546467 | 0.69 | HDAC1 (0.58) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL2411022 | 0.69 | HDAC1 (0.75) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL3551388 | 0.69 | HDAC1 (0.60) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL3546721 | 0.68 | NPC1 (0.53) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL3546718 | 0.68 | HDAC1 (0.53) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL1079396 | 0.68 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904452-A2 | HISTONE DEACETYLASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007011626-A2 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2007-01-25 | — | — | WO | disclosed |