Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719198 | 0.86 | MAPK14 (0.57) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL4761912 | 0.85 | MAPK14 (0.51) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL6004854 | 0.83 | MAPK14 (0.46) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL6004040 | 0.81 | CSNK1E (0.50) | MAPK14CSNK1DCSNK1EMAP4K4 | |
| SCHEMBL6004451 | 0.81 | CSNK1D (0.48) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL4721253 | 0.80 | TLR7 (0.47) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL4915605 | 0.80 | MAPK14 (0.47) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL6003859 | 0.80 | MAPK14 (0.54) | MAPK14CSNK1DCSNK1ETLR7EGFR | |
| SCHEMBL4723794 | 0.78 | MAPK14 (0.48) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL29126896 | 0.76 | TGFBR1 (0.44) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | KALYPSYS, INC. | 2006-11-09 | — | — | US | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | MAPK1, MAP3K1, MAPK4 | MAPK14 26/4885CSNK1D 1696/4885CSNK1E 1579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.