Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.56 |
| ▸ | GRK2 | P25098 | 13/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4789635 | 0.98 | ROCK2 (0.55) | ROCK2GRK2PDE10ANR1H2NR1H3 | |
| Bromide SCHEMBL4788732 | 0.98 | ROCK2 (0.55) | ROCK2GRK2PDE10ANR1H2NR1H3 | |
| SCHEMBL7910285 | 0.86 | ROCK2 (0.56) | ROCK2GRK2PDE10ANR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL14736164 | 0.84 | ROCK2 (0.55) | ROCK2GRK2PDE10ANR1H2NR1H3 | |
| SCHEMBL12079522 | 0.83 | NR1H2 (0.66) | ROCK2GRK2NR1H2NR1H3 | |
| SCHEMBL3822424 | 0.80 | RET (0.62) | ROCK2GRK2NR1H2NR1H3 | |
| SCHEMBL16510587 | 0.80 | SMN1; SMN2 (0.58) | NR1H2NR1H3KDM4E | |
| SCHEMBL6037006 | 0.78 | ROCK2 (0.54) | ROCK2GRK2PDE10A | |
| SCHEMBL5451247 | 0.77 | ROCK2 (0.52) | ROCK2GRK2PDE10ANR1H2NR1H3 | |
| SCHEMBL14289634 | 0.77 | ROCK2 (0.64) | ROCK2GRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008011557-A2 | HETEROARYL INHIBITORS OF RHO KINASE | BORCHARDT ALLEN J (US) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008011557-A2 | HETEROARYL INHIBITORS OF RHO KINASE | BORCHARDT ALLEN J (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | ROCK1, ROCK2, RHOA | ROCK2 2/4885GRK2 254/4885PDE10A 1124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.