Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789791 | 1.00 | BRAF (0.52) | BRAFMEN1KMT2AMAPTRAF1 | |
| SCHEMBL4760404 | 0.85 | BRAF (0.52) | BRAFRAF1MAPK14 | |
| SCHEMBL5622507 | 0.84 | BRAF (0.51) | BRAFRAF1MAPK14 | |
| SCHEMBL4655952 | 0.81 | BRAF (0.80) | BRAF | |
| SCHEMBL4760049 | 0.81 | BRAF (0.53) | BRAFRAF1MAPK14 | |
| SCHEMBL4761959 | 0.81 | BRAF (0.66) | BRAFRAF1MAPK14 | |
| SCHEMBL4656854 | 0.79 | BRAF (0.76) | BRAFMEN1KMT2AMAPT | |
| SCHEMBL4791490 | 0.79 | BRAF (0.67) | BRAFRAF1MAPK14 | |
| SCHEMBL3171563 | 0.78 | KDM4E (0.54) | BRAF | |
| SCHEMBL4790686 | 0.77 | BRAF (0.46) | BRAFMEN1KMT2ARAF1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996594-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-12-03 | — | — | EP | claimed |
| WO-2007109093-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | WYETH (US) | 2007-09-27 | — | — | WO | claimed |