Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3171563 | 0.86 | KDM4E (0.54) | BRAF | |
| SCHEMBL4760049 | 0.80 | BRAF (0.53) | BRAFRAF1MAPK14 | |
| SCHEMBL4655907 | 0.78 | BRAF (0.76) | BRAF | |
| SCHEMBL4789792 | 0.77 | BRAF (0.52) | BRAFMEN1KMT2ARAF1MAPK14 | |
| SCHEMBL4789791 | 0.77 | BRAF (0.52) | BRAFMEN1KMT2ARAF1MAPK14 | |
| SCHEMBL4760404 | 0.77 | BRAF (0.52) | BRAFRAF1MAPK14 | |
| SCHEMBL11465926 | 0.76 | BRAF (0.56) | BRAFMEN1KMT2A | |
| SCHEMBL5622507 | 0.76 | BRAF (0.51) | BRAFRAF1MAPK14 | |
| SCHEMBL11465978 | 0.76 | KDM4E (0.52) | BRAF | |
| SCHEMBL5621150 | 0.76 | ALDH1A1 (0.46) | BRAFGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996594-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007109093-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |