Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 2/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3025575 | 1.00 | LTA4H (0.42) | LTA4HENPP2SIGMAR1PPARGPPARA | |
| SCHEMBL3035481 | 0.94 | LTA4H (0.43) | LTA4HENPP2SIGMAR1PPARGPPARA | |
| SCHEMBL3035623 | 0.92 | IDH1 (0.37) | LTA4HSIGMAR1HCRTR1HCRTR2IDH1 | |
| SCHEMBL3030395 | 0.85 | LTA4H (0.44) | LTA4HSIGMAR1HCRTR1HCRTR2 | |
| SCHEMBL3032148 | 0.83 | LTA4H (0.55) | LTA4H | |
| SCHEMBL3035446 | 0.81 | KMT2A (0.38) | LTA4HHCRTR1HCRTR2IDH1 | |
| SCHEMBL3040988 | 0.79 | IDH1 (0.37) | LTA4HSIGMAR1HCRTR1HCRTR2IDH1 | |
| SCHEMBL31688123 | 0.79 | LTA4H (0.45) | LTA4HSIGMAR1HCRTR1HCRTR2 | |
| SCHEMBL3039178 | 0.79 | LTA4H (0.45) | LTA4HSIGMAR1HCRTR1HCRTR2 | |
| SCHEMBL3041244 | 0.77 | LTA4H (0.57) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976828-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | Schering Aktiengesellschaft (DE) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007079078-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-07-12 | — | — | WO | disclosed |