Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 7/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12044684 | 0.98 | KCNH2 (0.61) | CCR3ACHEKCNH2ABL1RIN1 | |
| SCHEMBL12040802 | 0.98 | KCNH2 (0.61) | CCR3ACHEKCNH2ABL1RIN1 | |
| SCHEMBL8908408 | 0.95 | CCR3 (0.63) | CCR3ACHEKCNH2ABL1RIN1 | |
| SCHEMBL4499901 | 0.90 | CCR3 (0.69) | CCR3ACHEBCHE | |
| SCHEMBL4499239 | 0.90 | CCR3 (0.69) | CCR3ACHEBCHE | |
| SCHEMBL69200 | 0.89 | CCR3 (0.67) | CCR3ACHEHRH3BCHE | |
| SCHEMBL3107807 | 0.89 | CCR3 (0.71) | CCR3ACHEBCHE | |
| SCHEMBL13596997 | 0.87 | KCNH2 (0.56) | CCR3ACHEKCNH2ABL1RIN1 | |
| SCHEMBL13596970 | 0.86 | HRH3 (0.56) | CCR3ACHEKCNH2ABL1RIN1 | |
| SCHEMBL7371344 | 0.86 | SIGMAR1 (0.67) | CCR3ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2980076-B1 | Pyrazolyl derivatives | UNIV DUNDEE (GB) | 2017-05-31 | — | — | EP | disclosed |
| EP-1935885-A3 | Melanin concentrating hormone receptor ligands : substituted 1-benzyl-4-aryl piperazine analogues. | NEUROGEN CORPORATION (US) | 2008-10-15 | — | — | EP | disclosed |
| EP-1935885-A2 | Melanin concentrating hormone receptor ligands : substituted 1-benzyl-4-aryl piperazine analogues. | NEUROGEN CORPORATION (US) | 2008-06-25 | — | — | EP | disclosed |
| US-7241765-B2 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues | NEUROGEN CORPORATION (US) | 2007-07-10 | — | — | US | disclosed |
| US-20060229298-A1 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues | HUTCHISON ALAN | 2006-10-12 | — | — | US | disclosed |
| US-20060183789-A1 | Methods for preventing and treating obesity in patients with mc4 receptor mutations | NEUROGEN CORPORATION | 2006-08-17 | — | — | US | disclosed |
| US-7081458-B2 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues | NEUROGEN CORP. (US) | 2006-07-25 | — | — | US | disclosed |
| CN-1703401-A | Substituted 1-benzyl-4-arylpiperazine analogs as ligands for melanin concentrating hormone receptors | NEUROGEN CORP (US) | 2005-11-30 | — | — | CN | disclosed |
| US-6953801-B2 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues | NEUROGEN CORPORATION (US) | 2005-10-11 | — | — | US | disclosed |
| US-20050182068-A1 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues | HUTCHISON ALAN (US) | 2005-08-18 | — | — | US | disclosed |
| US-20050065162-A1 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION | 2005-03-24 | — | — | US | disclosed |
| WO-2004028453-A2 | METHODS FOR PREVENTING AND TREATING OBESITY IN PATIENTS WITH MC4 RECEPTOR MUTATIONS | NEUROGEN CORPORATION (US) | 2004-04-08 | — | — | WO | disclosed |
| EP-1389189-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002094799-A3 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORP (US) | 2003-11-06 | — | — | WO | disclosed |
| WO-2002094799-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2002-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229298-A1 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues | MCHR1, MCHR2, MC1R | CCR3 823/4885ACHE 4359/4885KCNH2 3551/4885 |
| US-20050065162-A1 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | MCHR1, MCHR2, MC1R | CCR3 823/4885ACHE 4359/4885KCNH2 3551/4885 |
| US-20050182068-A1 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues | MCHR1, MCHR2, MC1R | CCR3 823/4885ACHE 4359/4885KCNH2 3551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.