Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036716 | 1.00 | LTA4H (0.59) | LTA4HALDH1A1PTGER4NR4A2CYP2C9 | |
| SCHEMBL3041244 | 0.91 | LTA4H (0.57) | LTA4HALDH1A1PTGER4NR4A2RXRA | |
| SCHEMBL3040886 | 0.89 | LTA4H (0.55) | LTA4HALDH1A1PTGER4NR4A2 | |
| SCHEMBL3032148 | 0.89 | LTA4H (0.55) | LTA4HALDH1A1PTGER4NR4A2RXRA | |
| SCHEMBL4790531 | 0.88 | LTA4H (0.57) | LTA4HPTGER4NR4A2S1PR1S1PR5 | |
| SCHEMBL3038132 | 0.88 | LTA4H (0.57) | LTA4HPTGER4NR4A2S1PR1S1PR5 | |
| SCHEMBL3042632 | 0.87 | LTA4H (0.56) | LTA4HS1PR1S1PR5 | |
| SCHEMBL3042634 | 0.87 | LTA4H (0.56) | LTA4HS1PR1S1PR5 | |
| SCHEMBL3041064 | 0.87 | LTA4H (0.53) | LTA4HALDH1A1PTGER4NR4A2RXRA | |
| SCHEMBL3036296 | 0.85 | LTA4H (0.56) | LTA4HPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976828-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | Schering Aktiengesellschaft (DE) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007079078-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-07-12 | — | — | WO | disclosed |