Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790618 | 0.89 | BRD4 (0.50) | BRD4TLR7CYP3A4CYP2C9PIK3CA | |
| SCHEMBL4543189 | 0.87 | BRD4 (0.49) | BRD4TLR7CYP3A4CYP2C9PIK3CA | |
| SCHEMBL14466065 | 0.86 | TLR7 (0.62) | BRD4TLR7CYP3A4CYP2C9PIK3CA | |
| Hydrochloric Acid SCHEMBL4761666 | 0.85 | TLR7 (0.61) | BRD4TLR7CYP3A4CYP2C9PIK3CA | |
| SCHEMBL4791720 | 0.85 | TLR7 (0.51) | BRD4TLR7CYP3A4CYP2C9PIK3CA | |
| SCHEMBL14465866 | 0.85 | MTOR (0.50) | BRD4TLR7CYP3A4CYP2C9PIK3CA | |
| SCHEMBL14466850 | 0.83 | TLR7 (0.47) | BRD4TLR7CYP3A4CYP2C9PIK3CA | |
| SCHEMBL4762754 | 0.83 | BRD4 (0.46) | BRD4TLR7CYP3A4CYP2C9PIK3CA | |
| SCHEMBL14465830 | 0.83 | BRD4 (0.44) | BRD4TLR7CYP3A4CYP2C9PIK3CA | |
| SCHEMBL4792037 | 0.83 | BRD4 (0.44) | BRD4TLR7CYP3A4CYP2C9PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968587-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | Coley Pharmaceutical, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007075468-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075468-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-07-05 | — | — | WO | disclosed |