Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 6/20 | 0.44 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.38 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30813147 | 0.81 | CNR1 (0.48) | CNR1GRIN1PREPGRIN2BPRMT5 | |
| SCHEMBL4832435 | 0.74 | CNR1 (0.55) | HTR1ADRD2HTR2AHTR6CNR1 | |
| SCHEMBL4493307 | 0.74 | CNR1 (0.49) | CNR1GRIN1PREPGRIN2BCYP3A4 | |
| SCHEMBL4838828 | 0.73 | CNR1 (0.47) | CNR1GRIN1GRIN2APREPCYP3A4 | |
| SCHEMBL406979 | 0.72 | HTR1A (0.58) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL4840238 | 0.71 | CNR1 (0.49) | CNR1GRIN1PREPGRIN2BCYP3A4 | |
| SCHEMBL4842112 | 0.71 | CNR1 (0.49) | CNR1GRIN1PREPGRIN2BPDE5A | |
| SCHEMBL4492965 | 0.71 | CNR1 (0.62) | CNR1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4479631 | 0.70 | CNR1 (0.64) | CNR1GRIN1PREPGRIN2BCYP3A4 | |
| SCHEMBL4477029 | 0.70 | CNR1 (0.67) | CNR1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891068-A1 | TRIAZOLOPYRIDINE DERIVATIVES AS CANNABINOID RECEPTOR 1 ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006138695-A1 | TRIAZOLOPYRIDINE DERIVATIVES AS CANNABINOID RECEPTOR 1 ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-28 | — | — | WO | disclosed |