Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 4/20 | 0.47 |
| ▸ | NAMPT | P43490 | 10/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790954 | 0.87 | NAMPT (0.47) | NAMPT | |
| SCHEMBL4760965 | 0.79 | NAMPT (0.45) | NAMPT | |
| SCHEMBL3702879 | 0.78 | NAMPT (0.72) | NAMPT | |
| SCHEMBL4715261 | 0.78 | NAMPT (0.40) | NAMPT | |
| SCHEMBL4760275 | 0.77 | NAMPT (0.39) | NAMPTDRD2SIGMAR1 | |
| SCHEMBL4717476 | 0.76 | NAMPT (0.42) | NAMPTTDP1 | |
| SCHEMBL4717909 | 0.75 | TNKS (0.40) | NAMPT | |
| SCHEMBL4718481 | 0.75 | PTGDR2 (0.38) | CACNA1GNAMPTTDP1 | |
| SCHEMBL4714941 | 0.74 | GRIN2B (0.39) | NAMPT | |
| SCHEMBL4717908 | 0.74 | NAMPT (0.39) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |
| US-6514964-B1 | Treating diseases, conditions or disorders mediated by integrin receptors, such as vitronectin and fibronectin receptors | AMGEN INC. | 2003-02-04 | — | — | US | disclosed |