Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 7/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791064 | 0.93 | CCR3 (0.42) | CCR3HTR2AFGFR1 | |
| SCHEMBL4791492 | 0.80 | KDR (0.43) | CCR3LCK | |
| SCHEMBL4717742 | 0.79 | LCK (0.43) | EPHX2CSNK2A1LCKMAPK14FGFR1 | |
| SCHEMBL4714363 | 0.78 | FLT3 (0.48) | EPHX2CSNK2A1LCKMAPK14 | |
| SCHEMBL4715839 | 0.77 | LCK (0.52) | EPHX2LCKMAPK14 | |
| SCHEMBL4716479 | 0.77 | BRAF (0.54) | — | |
| SCHEMBL4718731 | 0.77 | MAPK14 (0.49) | EPHX2LCKMAPK14FGFR1 | |
| SCHEMBL4717256 | 0.76 | FLT3 (0.47) | EPHX2CSNK2A1LCKMAPK14FGFR1 | |
| SCHEMBL4717402 | 0.76 | MCHR1 (0.51) | CCR3HTR2AEPHX2FGFR1 | |
| SCHEMBL4881029 | 0.74 | MAPK14 (0.54) | CSNK2A1LCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737463-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | claimed |