Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1271595 | 0.86 | POLB (0.79) | MTORPIK3CALMNAALDH1A1KDM4E | |
| SCHEMBL3600075 | 0.84 | MTOR (0.67) | MTORPIK3CALMNAALDH1A1KDM4E | |
| SCHEMBL1270892 | 0.83 | MTOR (0.63) | MTORPIK3CALMNAALDH1A1KDM4E | |
| SCHEMBL1271730 | 0.83 | MTOR (0.77) | MTORPIK3CALMNAALDH1A1KDM4E | |
| SCHEMBL739736 | 0.79 | MTOR (0.73) | MTORPIK3CALMNAALDH1A1KDM4E | |
| SCHEMBL3603559 | 0.78 | MTOR (0.70) | MTORPIK3CALMNAALDH1A1KDM4E | |
| SCHEMBL740384 | 0.78 | MTOR (1.00) | MTORPIK3CALMNAALDH1A1KDM4E | |
| SCHEMBL1272376 | 0.78 | MTOR (0.67) | MTORPIK3CALMNAALDH1A1KDM4E | |
| SCHEMBL1271555 | 0.77 | MTOR (0.64) | MTORPIK3CALMNAALDH1A1KDM4E | |
| SCHEMBL1271886 | 0.77 | MTOR (0.66) | MTORPIK3CALMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979325-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007080382-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2007-07-19 | — | — | WO | disclosed |