Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 6/20 | 0.30 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.30 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1278430 | 0.97 | HSD17B10 (0.32) | HSD17B10NAMPTALDH1A1HDAC1HDAC3 | |
| Fumaric Acid SCHEMBL1278431 | 0.90 | HSD17B10 (0.33) | MEN1POLBKMT2AL3MBTL1HSD17B10 | |
| Fumaric Acid SCHEMBL1278428 | 0.90 | HSD17B10 (0.33) | MEN1POLBKMT2AL3MBTL1HSD17B10 | |
| SCHEMBL4793307 | 0.85 | HCAR2 (0.38) | HCAR2MEN1POLBKMT2AL3MBTL1 | |
| Fumaric Acid SCHEMBL1278492 | 0.85 | NAMPT (0.40) | MEN1POLBKMT2AL3MBTL1HSD17B10 | |
| Fumaric Acid SCHEMBL1278489 | 0.85 | NAMPT (0.40) | MEN1POLBKMT2AL3MBTL1HSD17B10 | |
| SCHEMBL1580592 | 0.84 | EPHX2 (0.34) | HSD17B10NAMPTKAT5KAT8ALDH1A1 | |
| Fumaric Acid SCHEMBL1278703 | 0.84 | KAT8 (0.36) | MEN1POLBKMT2AL3MBTL1NAMPT | |
| Fumaric Acid SCHEMBL1278371 | 0.84 | NAMPT (0.35) | MEN1POLBKMT2AL3MBTL1NAMPT | |
| Fumaric Acid SCHEMBL1278699 | 0.84 | KAT8 (0.36) | MEN1POLBKMT2AL3MBTL1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919865-A1 | 1-HETEROCYCLYLSULFONYL, 2-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026916-A1 | 1-HETEROCYCLYLSULFONYL, 2-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-08 | — | — | WO | disclosed |