Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.46 |
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14466884 | 0.92 | TLR7 (0.51) | TLR7BRD4TLR8PIK3CDPIK3CA | |
| SCHEMBL4793842 | 0.89 | TLR7 (0.41) | TLR7BRD4TLR8PIK3CDPIK3CA | |
| SCHEMBL14465820 | 0.89 | TLR7 (0.53) | TLR7BRD4TLR8PIK3CDPIK3CA | |
| SCHEMBL4790754 | 0.87 | TLR7 (0.53) | TLR7BRD4TLR8PIK3CDPIK3CA | |
| SCHEMBL14466847 | 0.84 | TLR7 (0.54) | TLR7BRD4TLR8PIK3CDPIK3CA | |
| SCHEMBL1140942 | 0.79 | PIK3CA (0.35) | BRD4PIK3CDPIK3CAMTORCNR2 | |
| SCHEMBL4791340 | 0.77 | BRD4 (0.47) | TLR7BRD4TLR8PIK3CDPIK3CA | |
| SCHEMBL4543189 | 0.77 | BRD4 (0.49) | TLR7BRD4TLR8PIK3CDPIK3CA | |
| SCHEMBL14465845 | 0.76 | TLR7 (0.60) | TLR7BRD4TLR8PIK3CDPIK3CA | |
| SCHEMBL1141089 | 0.76 | PDE10A (0.34) | BRD4PIK3CDPIK3CACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968587-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | Coley Pharmaceutical, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007075468-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075468-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-07-05 | — | — | WO | disclosed |