Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 5/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.38 |
| ▸ | RELA | Q04206 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790633 | 0.72 | KLK7 (0.34) | NFKB1NFKB2RELAL3MBTL1KLK7 | |
| SCHEMBL13391275 | 0.70 | NFKB1 (0.42) | NFKB1NFKB2RELAGAAKMT2A | |
| SCHEMBL3692487 | 0.68 | NFKB1 (0.32) | NFKB1NFKB2RELA | |
| SCHEMBL3302910 | 0.68 | NFKB1 (0.32) | NFKB1NFKB2RELA | |
| SCHEMBL14515887 | 0.68 | CHRM2 (0.38) | L3MBTL1KLK7KLK5CHRM2CHRM1 | |
| SCHEMBL34475689 | 0.68 | CHRM2 (0.38) | L3MBTL1KLK7KLK5CHRM2CHRM1 | |
| SCHEMBL13391516 | 0.68 | NFKB1 (0.31) | NFKB1NFKB2RELA | |
| SCHEMBL2132635 | 0.67 | KLK7 (0.33) | L3MBTL1KLK7KLK5CHRM2CHRM1 | |
| SCHEMBL2132631 | 0.67 | KLK7 (0.33) | L3MBTL1KLK7KLK5CHRM2CHRM1 | |
| SCHEMBL4792104 | 0.67 | PLA2G10 (0.36) | L3MBTL1KLK7KLK5CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134681-B1 | TRANS-ANNULAR REARRANGEMENT OF ACTIVE LACTAMES | CENTRE NAT RECH SCIENT (FR) | 2012-05-16 | — | — | EP | disclosed |
| WO-2008125421-A1 | TRANS-ANNULAR REARRANGEMENT OF ACTIVE LACTAMES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2008-10-23 | — | — | WO | disclosed |