SCHEMBL4792306

SCHEMBL4792306

COc1cnc2cccc(C(O)(CO)C3CCC(NC/C=C/c4cc(F)ccc4F)CC3)c2n1

nearest known ligand 0.46

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 2/20 0.37
KCNH2 Q12809 9/20 0.34
HPGDS O60760 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3375808 0.80 KCNH2 (0.40) SLC2A1KCNH2
SCHEMBL4792309 0.80 KCNH2 (0.40) SLC2A1KCNH2
SCHEMBL3378451 0.80 KCNH2 (0.40) SLC2A1KCNH2
SCHEMBL3378448 0.80 KCNH2 (0.40) SLC2A1KCNH2
SCHEMBL3378445 0.80 KCNH2 (0.40) SLC2A1KCNH2
SCHEMBL4792304 0.80 KCNH2 (0.40) SLC2A1KCNH2
SCHEMBL3376816 0.77 KCNH2 (0.40) SLC2A1KCNH2
SCHEMBL3373336 0.75 PTPN11 (0.35) HPGDS
SCHEMBL3372984 0.75 PTPN11 (0.35) HPGDS
SCHEMBL3375788 0.73 KCNH2 (0.44) SLC2A1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1987040-A1 ETHANOL OR 1,2-ETHANEDIOL CYCLOHEXYL ANTIBIOTIC DERIVATIVES Actelion Pharmaceuticals Ltd. (CH) 2008-11-05 EP claimed
WO-2007093963-A1 ETHANOL OR 1,2-ETHANEDIOL CYCLOHEXYL ANTIBIOTIC DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2007-08-23 WO claimed