Sugi Predict

Sugi Predict / Compounds / SCHEMBL4792307

SCHEMBL4792307

SCHEMBL4792307

Clc1ccc(CNCc2ccc(-c3ccnc4[nH]ccc34)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IKBKB O14920 7/20 0.56
▸ CHUK O15111 6/20 0.56
▸ ROCK1 Q13464 3/20 0.56
▸ AURKB Q96GD4 2/20 0.56
▸ DAPK3 O43293 1/20 0.56
▸ JAK2 O60674 1/20 0.56
▸ PRKD3 O94806 1/20 0.56
▸ MAP4K4 O95819 1/20 0.56
▸ PAK4 O96013 1/20 0.56
▸ CSF1R P07333 1/20 0.56
▸ RET P07949 1/20 0.56
▸ IGF1R P08069 1/20 0.56
▸ FGFR1 P11362 1/20 0.56
▸ PRKACA P17612 1/20 0.56
▸ FLT1 P17948 1/20 0.56
▸ LTK P29376 1/20 0.56
▸ GRK5 P34947 1/20 0.56
▸ KDR P35968 1/20 0.56
▸ MAP2K2 P36507 1/20 0.56
▸ MAPK8 P45983 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30674332 0.89 IKBKB (0.70) IKBKBCHUKROCK1AURKBDAPK3
SCHEMBL26930376 0.89 IKBKB (0.70) IKBKBCHUKROCK1AURKBDAPK3
SCHEMBL4791504 0.88 IKBKB (0.70) IKBKBCHUKROCK1AURKBDAPK3
SCHEMBL4790931 0.88 IKBKB (0.57) IKBKBCHUKROCK1AURKBDAPK3
SCHEMBL4791015 0.87 IKBKB (0.55) IKBKBCHUKROCK1AURKBDAPK3
SCHEMBL4791930 0.86 IKBKB (0.56) IKBKBCHUKROCK1AURKBDAPK3
SCHEMBL4791911 0.86 IKBKB (0.56) IKBKBCHUKROCK1AURKBDAPK3
SCHEMBL4792515 0.85 IKBKB (0.56) IKBKBCHUKROCK1AURKBDAPK3
SCHEMBL4793312 0.85 IKBKB (0.57) IKBKBCHUKROCK1AURKBDAPK3
SCHEMBL4792683 0.83 NUDT1 (0.63) IKBKBCHUKROCK1AURKBDAPK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208053-A1 Fused heterobicyclic kinase inhibitors OSI PHARMACEUTICALS, INC. 2007-09-06 — — US claimed
EP-1979353-A2 FUSED HETEROBICYCLIC KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2008-10-15 — — EP disclosed
US-20070208053-A1 Fused heterobicyclic kinase inhibitors OSI PHARMACEUTICALS, INC. 2007-09-06 — — US disclosed
US-20070208053-A1 Fused heterobicyclic kinase inhibitors OSI PHARMACEUTICALS, INC. 2007-09-06 — — US disclosed
US-20070208053-A1 Fused heterobicyclic kinase inhibitors OSI PHARMACEUTICALS, INC. 2007-09-06 — — US disclosed
WO-2007084667-A2 FUSED HETEROBICYCLIC KINASE INHIBITORS OSI PHARMACEUTICAL, INC. (US) 2007-07-26 — — WO disclosed
WO-2007084667-A2 FUSED HETEROBICYCLIC KINASE INHIBITORS OSI PHARMACEUTICAL, INC. (US) 2007-07-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208053-A1 Fused heterobicyclic kinase inhibitors MAP2K5, MAP2K7, MAP2K2 IKBKB 138/4885CHUK 31/4885ROCK1 560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.