Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4792135 | 0.89 | HDAC6 (0.40) | CNR2DRD2TBXA2RGAAHTT | |
| SCHEMBL4792261 | 0.81 | HRH3 (0.52) | CNR2DRD2TBXA2RHTT | |
| SCHEMBL2878939 | 0.77 | HDAC6 (0.46) | CNR2HDAC1 | |
| SCHEMBL4889725 | 0.76 | KCNH2 (0.42) | CNR2DRD2TBXA2RHDAC1KCNH2 | |
| SCHEMBL2887550 | 0.76 | SLC6A4 (0.42) | HDAC1 | |
| SCHEMBL4167425 | 0.74 | ESR1 (0.47) | HDAC1KCNH2 | |
| SCHEMBL4790226 | 0.74 | PPARG (0.43) | HDAC1KCNH2 | |
| SCHEMBL4791994 | 0.73 | PTAFR (0.41) | HDAC1KCNH2 | |
| SCHEMBL1812812 | 0.71 | SLC6A2 (0.35) | HTT | |
| SCHEMBL4793698 | 0.70 | KCNH2 (0.39) | KCNH2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |