Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4793576 | 0.93 | MEN1 (0.40) | KCNH2DRD2TBXA2RCNR2AGTR1 | |
| SCHEMBL4791508 | 0.91 | LMNA (0.42) | KCNH2DRD2TBXA2RCNR2HTT | |
| SCHEMBL4764354 | 0.90 | POLB (0.41) | GAAHTTALDH1A1 | |
| SCHEMBL4790935 | 0.90 | DRD2 (0.42) | KCNH2DRD2TBXA2RCNR2HRH3 | |
| SCHEMBL4764592 | 0.84 | HRH3 (0.54) | KCNH2PTAFRHDAC1HRH3 | |
| SCHEMBL4793698 | 0.83 | KCNH2 (0.39) | KCNH2HTTSMN1; SMN2 | |
| SCHEMBL4792764 | 0.81 | ADAM17 (0.46) | HTTPTAFRHRH3 | |
| SCHEMBL4765934 | 0.81 | MGLL (0.40) | ALDH1A1 | |
| SCHEMBL4724233 | 0.79 | HPGD (0.54) | GAAHDAC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4161023 | 0.78 | HRH3 (0.52) | KCNH2HTTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | claimed |