Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.30 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777314 | 0.82 | GAA (0.38) | NR1H2NR1H3MAPK1 | |
| SCHEMBL4777570 | 0.76 | GAA (0.43) | CYP51A1NR1H2NR1H3MAPK1 | |
| SCHEMBL4777561 | 0.71 | GAA (0.36) | MAPK1 | |
| SCHEMBL4775362 | 0.69 | GAA (0.39) | SLC6A2SLC6A4 | |
| SCHEMBL4771365 | 0.67 | GAA (0.37) | MAPK1 | |
| SCHEMBL4777347 | 0.67 | NR1H4 (0.39) | SLC6A2SLC6A4 | |
| SCHEMBL4776590 | 0.63 | GAA (0.42) | MAPK1 | |
| SCHEMBL4767994 | 0.61 | GAA (0.53) | — | |
| SCHEMBL4775060 | 0.60 | GAA (0.39) | — | |
| SCHEMBL16155387 | 0.58 | AOC3 (0.59) | AOC3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | claimed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |