Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 4/20 | 0.63 |
| ▸ | TEAD4 | Q15561 | 4/20 | 0.63 |
| ▸ | TEAD2 | Q15562 | 4/20 | 0.63 |
| ▸ | TEAD3 | Q99594 | 4/20 | 0.63 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25232718 | 0.88 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3SCN9A | |
| Hydrochloric Acid SCHEMBL25208896 | 0.87 | TEAD1 (0.60) | TEAD1TEAD4TEAD2TEAD3SCN9A | |
| SCHEMBL4792411 | 0.87 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3SCN9A | |
| SCHEMBL25239105 | 0.84 | TEAD1 (0.60) | TEAD1TEAD4TEAD2TEAD3SCN9A | |
| SCHEMBL30424432 | 0.84 | TEAD1 (0.60) | TEAD1TEAD4TEAD2TEAD3SCN9A | |
| Hydrochloric Acid SCHEMBL25237493 | 0.83 | TEAD1 (0.59) | TEAD1TEAD4TEAD2TEAD3SCN9A | |
| SCHEMBL4792507 | 0.82 | MAPT (0.47) | TEAD1TEAD4TEAD2TEAD3SCN9A | |
| SCHEMBL25237292 | 0.82 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3SCN9A | |
| SCHEMBL4794408 | 0.82 | TEAD1 (0.45) | TEAD1TEAD4TEAD2TEAD3RARG | |
| SCHEMBL25749012 | 0.81 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937647-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | Inpharmatica Limited (GB) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007036727-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |
| WO-2007036727-A1 | CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II | INPHARMATICA LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |