Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.60 |
| ▸ | TEAD4 | Q15561 | 3/20 | 0.60 |
| ▸ | TEAD2 | Q15562 | 3/20 | 0.60 |
| ▸ | TEAD3 | Q99594 | 3/20 | 0.60 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | GPR39 | O43194 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25239105 | 1.00 | TEAD1 (0.60) | TEAD1TEAD4TEAD2TEAD3PRMT1 | |
| Hydrochloric Acid SCHEMBL25237493 | 0.99 | TEAD1 (0.59) | TEAD1TEAD4TEAD2TEAD3PRMT1 | |
| SCHEMBL25274345 | 0.85 | TEAD1 (0.57) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL30469150 | 0.85 | TEAD1 (0.57) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25749012 | 0.85 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25232718 | 0.85 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25237292 | 0.84 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL4792952 | 0.84 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL4792411 | 0.84 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| Hydrochloric Acid SCHEMBL25208896 | 0.84 | TEAD1 (0.60) | TEAD1TEAD4TEAD2TEAD3PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436957-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2024-10-02 | — | — | EP | disclosed |
| CN-118302411-A | Therapeutic indazole compounds and methods of use thereof for the treatment of cancer | 基因泰克公司 | 2024-07-05 | — | — | CN | disclosed |
| WO-2023097195-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |