Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 3/20 | 0.35 |
| ▸ | PRKACG | P22612 | 3/20 | 0.35 |
| ▸ | PRKACB | P22694 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880209 | 0.84 | HRH3 (0.49) | LTA4HDDR1KDM4EHRH3 | |
| SCHEMBL2884152 | 0.83 | HRH3 (0.48) | HRH3 | |
| Hydrochloric Acid SCHEMBL2887059 | 0.80 | CYP11B1 (0.56) | CYP11B1CYP11B2HTTSMN1; SMN2MAPK1 | |
| SCHEMBL4566468 | 0.76 | CYP11B1 (0.58) | HTR6CYP11B1CYP11B2HTTSMN1; SMN2 | |
| SCHEMBL16434812 | 0.73 | BCHE (0.54) | BCHEACHEBACE1 | |
| SCHEMBL2031564 | 0.73 | BCHE (0.54) | BCHEACHEBACE1 | |
| SCHEMBL11453801 | 0.73 | BCHE (0.54) | BCHEACHEBACE1 | |
| SCHEMBL4763558 | 0.73 | CYP11B1 (0.48) | DDR1CYP11B1CYP11B2HTTSMN1; SMN2 | |
| SCHEMBL22533720 | 0.72 | CYP11B1 (0.40) | HTR6CYP11B1CYP11B2HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL16423436 | 0.72 | BCHE (0.52) | BCHEACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | claimed |