Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 5/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | QPCT | Q16769 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2881324 | 0.84 | HRH3 (0.52) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2887059 | 0.82 | CYP11B1 (0.56) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL4215258 | 0.78 | KDM1A (0.60) | LMNAKDM1AALDH1A1HRH3 | |
| SCHEMBL22254428 | 0.78 | KDM1A (0.60) | LMNAKDM1AALDH1A1HRH3 | |
| SCHEMBL5692019 | 0.78 | KDM1A (0.60) | LMNAKDM1AALDH1A1HRH3 | |
| Hydrochloric Acid SCHEMBL4222870 | 0.77 | KDM1A (0.58) | LMNAKDM1AALDH1A1HRH3 | |
| SCHEMBL15345063 | 0.75 | CYP11B1 (0.68) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL4792995 | 0.73 | LTA4H (0.37) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL2883883 | 0.73 | HRH3 (0.52) | KCNH2QPCTHRH3DDR1 | |
| SCHEMBL4942172 | 0.72 | MKNK1 (0.50) | CYP11B1CYP11B2HTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |