Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762104 | 0.87 | CRHR1 (0.43) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4767150 | 0.84 | CRHR1 (0.43) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4763293 | 0.83 | CRHR1 (0.44) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4763245 | 0.83 | CRHR1 (0.46) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4763287 | 0.81 | CRHR1 (0.41) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4762385 | 0.79 | CRHR1 (0.43) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4763067 | 0.79 | CRHR1 (0.43) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL4767336 | 0.78 | CRHR1 (0.42) | CRHR1DRD2HTR2AHTR7HTR6 | |
| SCHEMBL6639521 | 0.78 | CRHR1 (0.46) | CRHR1HTR7HTR1ACNR1 | |
| SCHEMBL13986668 | 0.77 | CRHR1 (0.42) | CRHR1DRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395591-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-06-04 | — | — | EP | disclosed |