Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | IDE | P14735 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1278296 | 0.95 | NAMPT (0.35) | HTR2CSLC6A4NAMPTRIPK1TACR1 | |
| SCHEMBL1278573 | 0.94 | NAMPT (0.35) | HTR2CSLC6A4NAMPTRIPK1TACR1 | |
| SCHEMBL1278815 | 0.89 | PTGER2 (0.32) | HTR2CSLC6A4NAMPTRIPK1TACR1 | |
| SCHEMBL1278709 | 0.86 | PTGER2 (0.33) | HTR2CSLC6A4NAMPTRIPK1TACR1 | |
| SCHEMBL4793921 | 0.85 | PTGER2 (0.33) | NAMPTIDEALDH1A1TSHRHTT | |
| SCHEMBL1157020 | 0.85 | TACR1 (0.41) | HTR2CSLC6A4NAMPTRIPK1TACR1 | |
| SCHEMBL1157207 | 0.84 | HTR2C (0.37) | HTR2CSLC6A4NAMPTRIPK1TACR1 | |
| SCHEMBL30367834 | 0.84 | CHRNB2 (0.37) | HTR2CSLC6A4NAMPTRIPK1TACR1 | |
| SCHEMBL1278556 | 0.84 | NAMPT (0.39) | NAMPTTACR1ALDH1A1TSHR | |
| SCHEMBL1278255 | 0.84 | GPBAR1 (0.35) | HTR2CSLC6A4NAMPTRIPK1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919865-A1 | 1-HETEROCYCLYLSULFONYL, 2-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026916-A1 | 1-HETEROCYCLYLSULFONYL, 2-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-08 | — | — | WO | disclosed |