Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.44 |
| ▸ | USP10 | Q14694 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | USP13 | Q92995 | 1/20 | 0.43 |
| ▸ | GRK6 | P43250 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 3/20 | 0.41 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4351514 | 0.80 | CTNNB1 (0.46) | NTRK1USP10PIK3C3USP13GRK6 | |
| SCHEMBL3337810 | 0.79 | APP (0.47) | NTRK1USP10PIK3C3USP13GRK6 | |
| SCHEMBL3336024 | 0.77 | EGFR (0.48) | NTRK1USP10PIK3C3USP13GRK6 | |
| SCHEMBL3340735 | 0.71 | PDE5A (0.43) | NTRK1USP10PIK3C3USP13APP | |
| SCHEMBL21055798 | 0.71 | LMNA (0.59) | NTRK1APPLMNAHTTSMN1; SMN2 | |
| SCHEMBL2591004 | 0.71 | RAD52 (0.68) | USP10PIK3C3USP13APPLMNA | |
| SCHEMBL3334087 | 0.68 | NTRK1 (0.41) | NTRK1USP10PIK3C3USP13APP | |
| SCHEMBL3334084 | 0.68 | NTRK1 (0.41) | NTRK1USP10PIK3C3USP13APP | |
| SCHEMBL4357491 | 0.68 | NTRK1 (0.47) | NTRK1USP10PIK3C3USP13GRK6 | |
| SCHEMBL2590855 | 0.68 | RAD52 (0.82) | NTRK1APPLMNACTNNB1TCF7L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009078-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |