Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluocinolone Acetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 10/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | PGR | P06401 | 5/20 | 1.00 |
| ▸ | AR | P10275 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.81 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.73 |
| ▸ | ESR1 | P03372 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluocinolone Acetonide SCHEMBL3101080 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ALMNAPGRAR | |
| Fluocinolone Acetonide SCHEMBL15256220 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ALMNAPGRAR | |
| Fluocinolone Acetonide SCHEMBL13046617 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ALMNAPGRAR | |
| Fluocinolone Acetonide SCHEMBL12323210 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ALMNAPGRAR | |
| Fluocinolone Acetonide SCHEMBL11911287 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ALMNAPGRAR | |
| Fluocinolone Acetonide SCHEMBL13799272 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ALMNAPGRAR | |
| Fluocinolone Acetonide SCHEMBL13695922 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ALMNAPGRAR | |
| Fluocinolone Acetonide SCHEMBL4116560 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ALMNAPGRAR | |
| Fluocinolone Acetonide SCHEMBL21153661 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ALMNAPGRAR | |
| Fluocinolone Acetonide SCHEMBL28266842 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ALMNAPGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 33212 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026103774-A1 | POLYPEPTIDE HAVING ANTI-ANGIOGENIC ACTIVITY AND USE THEREOF | �田润 | 2026-05-21 | — | — | WO | claimed |
| EP-4744657-A1 | THERAPEUTIC AGENT FOR HUMAN GRAFT VERSUS HOST DISEASE AND COMBINATION THEREOF | National University Corporation Okayama University (JP) | 2026-05-20 | — | — | EP | claimed |
| CN-122065192-A | Method for forecasting strong wind intensity level of intelligent grid by utilizing convection potential index | 湖北省气象台(长江流域气象台) | 2026-05-19 | — | — | CN | claimed |
| WO-2026097187-A1 | IMPROVED ROTARY DAMPING SYSTEM FOR A DRILL STRING USED FOR DTH AND ROTARY DRILLING | SOCIEDAD IMPORTADORA COMERCIALIZADORA Y DISTRIBUIDORA TOOLS EQUIPMENT LIMITADA (CL) | 2026-05-15 | — | — | WO | claimed |
| CN-122022013-A | Wind resource microscopic site selection method and system based on economy | 湖北省天顺零碳技术有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4736088-A1 | METHOD FOR SETTING UP AN ELECTRICAL TRANSPORTATION INFRASTRUCTURE OF A MINE, METHOD OF MINING IN A MINE, AND A PLANNING SYSTEM FOR A MINE | ABB SCHWEIZ AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4724040-A1 | TREATMENT OF PSORIASIS | TRADOVA (PTY) LTD (ZA) | 2026-04-15 | — | — | EP | claimed |
| EP-4724064-A1 | COMPOSITION COMPRISING A COMBINATION OF A CORTICOSTEROID AND A FLAVONOID FOR USE IN TREATING EYE-RELATED DISEASES | South East Technological University (IE) | 2026-04-15 | — | — | EP | claimed |
| US-20260080372-A1 | TIMING RECOMMENDATION OF SERVER DECOMMISSIONING | MICROSOFT TECHNOLOGY LICENSING LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| WO-1981000410-A1 | CYTOTOXIC NUCLEOSIDE-CORTICOSTEROID PHOSPHODIESTERS | RESEARCH CORP (US) | 1981-02-19 | — | — | WO | claimed |
| US-4244942-A | Creamy preparation containing steroid and process for the preparation thereof | TOKO YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1981-01-13 | — | — | US | claimed |
| US-4221787-A | Esteramide prodrugs of anti-inflammatory corticosteroids | INTERX RESEARCH CORPORATION (US) | 1980-09-09 | — | — | US | claimed |
| US-4185100-A | CORTICOSTEROID AND A HYDROTROPIC ACID DERIVATIVE, ENZYME INHIBITORS | JOHNSON & JOHNSON (US) | 1980-01-22 | — | — | US | claimed |
| US-4137311-A | CORTICOSTEROIDS, METAL ADDUCTS OF BIS(2-PYRIDYL-1-OXIDE)-DISULFIDE; DERMATITIS, ANTIINFLAMMATORY | WILLIAM H. RORER, INC. (US) | 1979-01-30 | — | — | US | claimed |
| US-4130643-A | STEROID, SUCROSE ESTER, SULFOXIDE | THE PROCTER & GAMBLE COMPANY (US) | 1978-12-19 | — | — | US | claimed |
| US-4083974-A | Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether | THE UPJOHN COMPANY (US) | 1978-04-11 | — | — | US | claimed |
| US-4017615-A | ESPECIALLY USEFUL FOR ANTIINFLAMMATORY TOPICAL CORTICOIDS | SYNTEX CORPORATION (PM) | 1977-04-12 | — | — | US | claimed |
| US-3966925-A | Lubricant for fitting and trial mounting of prosthodontic appliances | DENPAC CORPORATION 85 MYER STREET HACKENSACK NEW JERSEY 07601 A CORP OF NEW JERSEY | 1976-06-29 | — | — | US | claimed |
| US-3966924-A | B-METHASONE VALERATE, 5-FLUOROURACIL | ALLERGAN PHARMACEUTICALS (US) | 1976-06-29 | — | — | US | claimed |