Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.56 |
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4799960 | 0.97 | GRM1 (0.63) | GRM1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL4797632 | 0.88 | KMT2A (0.74) | GRM1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL4798176 | 0.83 | GRM1 (0.55) | GRM1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL4799557 | 0.82 | CSNK2A1 (0.52) | GRM1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL3341175 | 0.80 | GRM1 (0.59) | GRM1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL4800674 | 0.78 | GRM1 (0.57) | GRM1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL2828727 | 0.75 | KMT2A (0.80) | GRM1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL4797120 | 0.75 | GRM1 (0.59) | GRM1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL4798879 | 0.75 | NPC1 (0.59) | GRM1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL4732495 | 0.74 | MAPT (0.56) | GRM1KMT2ANPC1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | claimed |
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |