SCHEMBL4795618

CNC(=O)CN1C[C@H](C(=O)c2nccs2)C(c2cccc(F)c2C)[C@@H](C(=O)c2nccs2)C1.Cc1c(F)cccc1C1[C@@H](C(=O)c2nccs2)CN(CC(=O)N(C)C)C[C@@H]1C(=O)c1nccs1.Cc1c(F)cccc1C1[C@@H](C(=O)c2nccs2)CN(CC(N)=O)C[C@@H]1C(=O)c1nccs1.Cc1c(F)cccc1C1[C@@H](C(=O)c2nccs2)CN(CCO)C[C@@H]1C(=O)c1nccs1

nearest known ligand 0.32

Predicted protein targets (top 4)

	gene	UniProt	supporting neighbours	confidence
▸	EED	O75530	1/20	0.32

▸	KDM4E	B2RXH2	1/20	0.30

▸	LMNA	P02545	1/20	0.30

▸	KMT2A	Q03164	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4023706	0.87	KMT2A (0.37)	KDM4ELMNAKMT2A
SCHEMBL4023704	0.87	KMT2A (0.37)	KDM4ELMNAKMT2A
SCHEMBL4020952	0.86	EED (0.37)	EEDKDM4ELMNAKMT2A
SCHEMBL4020948	0.86	EED (0.37)	EEDKDM4ELMNAKMT2A
SCHEMBL4021790	0.86	KDM4E (0.39)	KDM4ELMNAKMT2A
SCHEMBL4021793	0.86	KDM4E (0.39)	KDM4ELMNAKMT2A
SCHEMBL4026176	0.75	KMT2A (0.39)	KDM4EKMT2A
SCHEMBL4749424	0.74	EED (0.42)	EED
SCHEMBL4749426	0.74	EED (0.42)	EED
SCHEMBL4024616	0.74	KMT2A (0.32)	KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1962846-A2	CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS	Cytokinetics, Inc. (US)	2008-09-03	—	—	EP	disclosed
WO-2007059323-A2	CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS	CYTOKINETICS, INC. (US)	2007-05-24	—	—	WO	disclosed