Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 4/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3270268 | 0.91 | KCNH2 (0.46) | KCNH2KIF11HSD17B3KDM4EGLA | |
| SCHEMBL3269493 | 0.91 | KCNH2 (0.46) | KCNH2KIF11HSD17B3KDM4EGLA | |
| SCHEMBL12735758 | 0.81 | KCNH2 (0.40) | KCNH2KIF11HSD17B3KDM4EGLA | |
| SCHEMBL11920180 | 0.80 | KIF11 (0.51) | KCNH2KIF11HSD17B3KDM4EGLA | |
| SCHEMBL3313494 | 0.80 | KCNH2 (0.43) | KCNH2KIF11MCHR1MAOB | |
| SCHEMBL3271196 | 0.79 | KIF11 (0.58) | KCNH2KIF11HSD17B3KDM4EGLA | |
| SCHEMBL3268480 | 0.79 | KCNH2 (0.37) | KCNH2KIF11GLAMCHR1NQO1 | |
| SCHEMBL13309014 | 0.79 | KCNH2 (0.44) | KCNH2KIF11HSD17B3KDM4EGLA | |
| SCHEMBL10192157 | 0.77 | PPARG (0.47) | KCNH2KIF11HSD17B3KDM4EGLA | |
| SCHEMBL3269903 | 0.77 | KIF11 (0.45) | KCNH2KIF11HSD17B3KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956908-A2 | CERTAIN COMPOSITIONS AND METHODS OF TREATMENT | Cytokinetics, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007067752-A2 | CERTAIN COMPOSITIONS AND METHODS OF TREATMENT | CYTOKINETICS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |