Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 10/20 | 0.59 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.47 |
| ▸ | MERTK | Q12866 | 2/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3293656 | 0.93 | CSF1R (0.69) | CSF1RCSNK2A1FGFR1SRCFGFR2 | |
| SCHEMBL3290854 | 0.92 | CSF1R (0.56) | CSF1RCSNK2A1FGFR1SRCFGFR2 | |
| SCHEMBL3290585 | 0.89 | CSF1R (0.54) | CSF1RFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL3290621 | 0.88 | CSF1R (0.75) | CSF1RCSNK2A1SRCMERTK | |
| SCHEMBL28522950 | 0.87 | CSF1R (0.53) | CSF1RTYRO3MERTKGAS6KDM4E | |
| SCHEMBL3290842 | 0.86 | CSF1R (0.62) | CSF1RCSNK2A1MERTK | |
| SCHEMBL3290711 | 0.85 | CSF1R (0.69) | CSF1RSRC | |
| SCHEMBL28527347 | 0.84 | CSF1R (0.57) | CSF1RKDM4EALDH1A1HSD17B10POLB | |
| SCHEMBL3293646 | 0.84 | CSF1R (0.59) | CSF1RKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3292644 | 0.83 | CSF1R (0.77) | CSF1RFGFR1SRCFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | claimed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | claimed |