Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776885 | 0.90 | PIK3CA (0.52) | KDM4EMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4774759 | 0.90 | MEN1 (0.40) | KDM4EMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4795493 | 0.79 | PIP4K2A (0.48) | KDM4EMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3937437 | 0.79 | CYP3A4 (0.38) | CYP1A2CYP3A4TP53EPHX2LMNA | |
| SCHEMBL4776483 | 0.77 | CYP1A2 (0.46) | CYP1A2CYP3A4CYP2C19MAPK1PROKR1 | |
| SCHEMBL3925104 | 0.77 | KCNK3 (0.41) | MEN1CYP1A2CYP3A4KMT2AHPGD | |
| SCHEMBL3937931 | 0.77 | LMNA (0.49) | MEN1KMT2AGAAHPGDLMNA | |
| SCHEMBL27991055 | 0.76 | PIK3CA (0.58) | PROKR1PIK3CAMAPK14PRKD3PRKD1 | |
| SCHEMBL3930613 | 0.73 | PIK3CA (0.67) | KDM4EHPGDPIK3CAMAPK14DYRK1A | |
| SCHEMBL3930503 | 0.71 | NAMPT (0.49) | CYP1A2CYP3A4CYP2C19KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280891-A1 | Anti-cancer agents and uses thereof | LOCUS PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | US | disclosed |
| WO-2008008059-A1 | ANTI-CANCER AGENTS ANS USES THEREOF | LOCUS PHARMACEUTICALS, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280891-A1 | Anti-cancer agents and uses thereof | NR2E3, RB1, CBR3 | KDM4E 3845/4885MEN1 1354/4885CYP1A2 3628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.