Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.40 |
| ▸ | NMT2 | O60551 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5387687 | 0.78 | SLC6A4 (0.59) | APPHTR2CADRB2HTR6HTR2A | |
| SCHEMBL30877229 | 0.76 | KDM4E (0.52) | APPSLC6A4HTR1FHTR1ADRD2 | |
| SCHEMBL18324791 | 0.76 | KDM4E (0.55) | SLC6A4HTR1FHTR1ADRD2 | |
| SCHEMBL18324804 | 0.76 | TDO2 (0.41) | APPHTR2ASLC6A4HTR1FDRD2 | |
| SCHEMBL2904310 | 0.75 | HTR2A (0.64) | APPHTR2CADRB2HTR2ASLC6A4 | |
| SCHEMBL30275187 | 0.75 | HTR2A (0.64) | APPHTR2CADRB2HTR2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL6248133 | 0.74 | HTR2C (0.63) | APPHTR2CADRB2HTR2ASLC6A4 | |
| SCHEMBL30877261 | 0.74 | KDM4E (0.44) | APPHTR2CHTR2ASLC6A4HTR1F | |
| SCHEMBL2781509 | 0.72 | HTR2C (0.62) | APPHTR2CADRB2HTR6HTR2A | |
| SCHEMBL17229881 | 0.71 | HTR2C (0.46) | HTR2CSLC6A4SLC6A2SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008015516-A1 | FUSED TRICYCLIC HETEROCYCLES FOR THE TREATMENT OF SCHIZOPHRENIA | PFIZER PRODUCTS INC. (US) | 2008-02-07 | — | — | WO | disclosed |