SCHEMBL4796636

SCHEMBL4796636

CC1OCC(C)n2c1nc1c(N)nc3ccccc3c12

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 18/20 0.45
TLR8 Q9NR97 8/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2087126 1.00 TLR7 (0.45) TLR7TLR8
SCHEMBL2088857 0.84 TLR7 (0.47) TLR7TLR8
SCHEMBL1773813 0.78 TLR7 (0.44) TLR7TLR8
SCHEMBL10237186 0.78 TLR7 (0.44) TLR7TLR8
SCHEMBL2087803 0.78 LRRK2 (0.41)
SCHEMBL202388 0.72 TLR7 (0.44) TLR7TLR8
SCHEMBL203469 0.72 TLR7 (0.44) TLR7TLR8
SCHEMBL205116 0.72 TLR7 (0.44) TLR7TLR8
SCHEMBL1774780 0.69 TLR7 (0.42) TLR7TLR8
SCHEMBL202478 0.69 TLR7 (0.41) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008008432-A2 SUBSTITUTED CHIRAL FUSED( 1,2) IMIDAZO (4,5-C) RING COMPOUNDS AND METHODS COLEY PHARMACEUTICAL GROUP, INC. (US) 2008-01-17 WO disclosed