Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.62 |
| ▸ | HTR2C | P28335 | 8/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783291 | 0.87 | HTR2A (0.61) | HTR2AHTR2CALDH1A1KCNH2ABL1 | |
| SCHEMBL14205208 | 0.87 | HTR2A (0.61) | HTR2AHTR2CKCNH2 | |
| SCHEMBL4782575 | 0.87 | HTR2A (0.65) | HTR2AHTR2CALDH1A1KCNH2ABL1 | |
| SCHEMBL4781852 | 0.86 | HTR2A (0.66) | HTR2AHTR2CALDH1A1KCNH2ABL1 | |
| SCHEMBL4784431 | 0.86 | HTR2A (0.66) | HTR2AHTR2CALDH1A1KCNH2ABL1 | |
| SCHEMBL4784682 | 0.85 | HTR2A (0.62) | HTR2AHTR2CALDH1A1KCNH2ABL1 | |
| SCHEMBL4784566 | 0.84 | HTR2A (0.62) | HTR2AHTR2CALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4794769 | 0.84 | HTR2A (0.67) | HTR2AHTR2CKCNH2ABL1BCR | |
| SCHEMBL4783248 | 0.84 | HTR2A (0.67) | HTR2AHTR2CMAPTKCNH2ABL1 | |
| SCHEMBL4732167 | 0.82 | HTR2A (0.65) | HTR2AHTR2CALDH1A1KCNH2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |