Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.38 |
| ▸ | BRAF | P15056 | 13/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729516 | 0.91 | RAF1 (0.39) | RAF1BRAFTRPV1NAMPTMEN1 | |
| SCHEMBL4727399 | 0.87 | RAF1 (0.40) | RAF1BRAFTRPV1NAMPTMEN1 | |
| SCHEMBL4729502 | 0.85 | NPC1 (0.40) | RAF1BRAFTRPV1NAMPTMEN1 | |
| SCHEMBL4727387 | 0.85 | RAF1 (0.39) | RAF1BRAFTRPV1NAMPTMEN1 | |
| SCHEMBL4780212 | 0.84 | RAF1 (0.37) | RAF1BRAFTRPV1NAMPTMEN1 | |
| SCHEMBL4729210 | 0.82 | TRPV1 (0.42) | RAF1BRAFTRPV1 | |
| SCHEMBL4726226 | 0.81 | RAF1 (0.46) | RAF1BRAFTRPV1MEN1KMT2A | |
| SCHEMBL4729484 | 0.81 | TRPV1 (0.41) | RAF1BRAFTRPV1 | |
| SCHEMBL4729212 | 0.81 | TRPV1 (0.41) | RAF1BRAFTRPV1 | |
| SCHEMBL4726861 | 0.80 | TEK (0.47) | RAF1BRAFTRPV1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |