Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 7/20 | 0.41 |
| ▸ | BRAF | P15056 | 5/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729484 | 0.92 | TRPV1 (0.41) | TRPV1HDAC3HDAC6RAF1BRAF | |
| SCHEMBL4729212 | 0.92 | TRPV1 (0.41) | TRPV1HDAC3HDAC6RAF1BRAF | |
| SCHEMBL4729549 | 0.88 | BTK (0.40) | TRPV1HDAC3HDAC6RAF1BRAF | |
| SCHEMBL4781066 | 0.88 | MAPK14 (0.55) | RAF1EPHA3FRKMAPK14 | |
| SCHEMBL4730164 | 0.88 | MAPK14 (0.53) | RAF1BRAFEPHA3FRKMAPK14 | |
| SCHEMBL14292743 | 0.88 | TRPV1 (0.39) | TRPV1HDAC3HDAC6RAF1BRAF | |
| SCHEMBL4726226 | 0.88 | RAF1 (0.46) | TRPV1HDAC3HDAC6RAF1BRAF | |
| SCHEMBL4726798 | 0.87 | RAF1 (0.42) | TRPV1HDAC3HDAC6RAF1BRAF | |
| SCHEMBL4727602 | 0.87 | RAF1 (0.42) | TRPV1HDAC3HDAC6RAF1BRAF | |
| SCHEMBL4729516 | 0.86 | RAF1 (0.39) | TRPV1HDAC3HDAC6RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |