Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | FES | P07332 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CLK3 | P49761 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580554 | 0.84 | AURKA (0.60) | AURKAAURKBTPX2MAPK14ULK1 | |
| SCHEMBL580553 | 0.72 | LTA4H (0.36) | AURKAAURKBMAPK14ULK1RPS6KA5 | |
| SCHEMBL580633 | 0.71 | AURKA (0.65) | AURKAAURKBTPX2MAPK14ULK1 | |
| SCHEMBL580402 | 0.71 | AURKA (0.65) | AURKAAURKBTPX2MAPK14ULK1 | |
| SCHEMBL580405 | 0.70 | AURKA (0.77) | AURKAAURKBTPX2MAPK14ULK1 | |
| SCHEMBL581667 | 0.70 | AURKA (0.69) | AURKAAURKBTPX2MAPK14ULK1 | |
| SCHEMBL580503 | 0.70 | AURKA (0.64) | AURKAAURKBTPX2MAPK14ULK1 | |
| SCHEMBL4791892 | 0.70 | AURKA (0.45) | AURKAAURKBTPX2MAPK14ULK1 | |
| SCHEMBL580643 | 0.69 | AURKB (0.71) | AURKAAURKBTPX2 | |
| SCHEMBL580785 | 0.68 | AURKB (0.79) | AURKAAURKBTPX2MAPK14ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |