Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.44 |
| ▸ | CTSD | P07339 | 10/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 10/20 | 0.39 |
| ▸ | REN | P00797 | 3/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733764 | 0.87 | BACE1 (0.60) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL4785466 | 0.77 | BACE1 (0.46) | BACE1CTSDBACE2REN | |
| SCHEMBL4242565 | 0.76 | BACE1 (0.70) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL4899108 | 0.75 | BACE1 (0.41) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL4109626 | 0.73 | BACE1 (0.58) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL2084875 | 0.71 | BACE1 (0.43) | BACE1BACE2CYP3A4GPR55 | |
| SCHEMBL13263906 | 0.71 | BACE1 (0.58) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL7886978 | 0.71 | BACE1 (0.66) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL4785029 | 0.71 | BACE1 (0.55) | BACE1CTSDBACE2RENAPP | |
| SCHEMBL4784419 | 0.71 | BACE1 (0.55) | BACE1CTSDBACE2RENAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |