SCHEMBL4800256

SCHEMBL4800256

CCCCCCCc1cnc(-c2ccc(F)cc2)nc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 5/20 0.67
RAB9A P51151 6/20 0.63
SMN1; SMN2 Q16637 4/20 0.63
MAPT P10636 4/20 0.63
KDM4E B2RXH2 2/20 0.63
MEN1 O00255 2/20 0.63
ALDH1A1 P00352 2/20 0.63
KMT2A Q03164 2/20 0.63
HSD17B10 Q99714 2/20 0.63
USP2 O75604 1/20 0.63
GAA P10253 1/20 0.63
HPGD P15428 1/20 0.63
NPC1 O15118 4/20 0.49
STAT3 P40763 1/20 0.49
ATM Q13315 1/20 0.49
NFKB1 P19838 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.44
CASP3 P42574 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10562556 1.00 RARB (0.67) RARBRAB9ASMN1; SMN2MAPTKDM4E
SCHEMBL10505457 1.00 RARB (0.67) RARBRAB9ASMN1; SMN2MAPTKDM4E
SCHEMBL4801321 1.00 RARB (0.67) RARBRAB9ASMN1; SMN2MAPTKDM4E
SCHEMBL10505564 1.00 RARB (0.67) RARBRAB9ASMN1; SMN2MAPTKDM4E
SCHEMBL10558487 1.00 RARB (0.67) RARBRAB9ASMN1; SMN2MAPTKDM4E
SCHEMBL10555573 1.00 RARB (0.67) RARBRAB9ASMN1; SMN2MAPTKDM4E
SCHEMBL5354918 0.98 RARB (0.64) RARBRAB9ASMN1; SMN2MAPTKDM4E
SCHEMBL10501562 0.97 RARB (0.63) RARBRAB9ASMN1; SMN2MAPTKDM4E
SCHEMBL10501354 0.97 RARB (0.63) RARBRAB9ASMN1; SMN2MAPTKDM4E
SCHEMBL8448885 0.97 RARB (0.62) RARBRAB9ASMN1; SMN2MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0123907-B1 FLUOROPYRIMIDINE DERIVATIVES Chisso Corporation (JP) 1989-07-26 EP claimed
US-7445818-B2 Matrix liquid crystal display MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2008-11-04 US disclosed
US-20070275182-A1 Matrix liquid crystal display WEBER GEORG 2007-11-29 US disclosed
US-7186447-B2 Two plane parallel support plates with frame form cell, with integrated non-linear elements for switching individual picture elements on support plates, and nematic liquid crystal mixture is present in cell, having positive dielectric anisotropy and high resistivity MERCK PATENT GMBH (DE) 2007-03-06 US disclosed
US-20050196551-A1 Matrix liquid crystal display WEBER GEORG (DE) 2005-09-08 US disclosed
US-6905740-B2 The invention relates to a matrix liquid crystal display containing integrated non-linear elements and a liquid crystal mixture which has a particularly high resistivity. MERCK PATENT GMBH (DE) 2005-06-14 US disclosed
US-20030207046-A1 Matrix liquid crystal display MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2003-11-06 US disclosed
US-6562419-B1 Matrix liquid crystal display MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2003-05-13 US disclosed
US-6004479-A FLUOROETHERS FOR LIQUID CRYSTAL DISPLAYS AND DIELECTRICS MERCK KGAA (DE) 1999-12-21 US disclosed
EP-0394419-B2 MATRIX LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 1999-10-06 EP disclosed
WO-1991010716-A1 MATRIX LIQUID CRYSTAL DISPLAY MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1991-07-25 WO disclosed
EP-0414048-A2 Matrix-liquid crystal display MERCK PATENT GmbH (DE) 1991-02-27 EP disclosed
WO-1991000898-A1 SUPER-TWIST LIQUID CRYSTAL DISPLAY MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1991-01-24 WO disclosed
EP-0394419-A1 MATRIX LIQUID CRYSTAL DISPLAY. MERCK PATENT GMBH (DE) 1990-10-31 EP disclosed
WO-1990004623-A1 MATRIX LIQUID CRYSTAL DISPLAY MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1990-05-03 WO disclosed
EP-0365962-A1 Matrix-type liquid-crystal display MERCK PATENT GmbH (DE) 1990-05-02 EP disclosed
EP-0126949-B1 FLUORINE-CONTAINING PYRIMIDINE DERIVATIVES MERCK PATENT GmbH (DE) 1989-09-27 EP disclosed
EP-0123907-B1 FLUOROPYRIMIDINE DERIVATIVES Chisso Corporation (JP) 1989-07-26 EP disclosed
US-4812258-A LIQUID CRYSTAL DIELECTRICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1989-03-14 US disclosed
EP-0126949-A2 Fluorine-containing pyrimidine derivatives MERCK PATENT GmbH (DE) 1984-12-05 EP disclosed