Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.56 |
| ▸ | MC4R | P32245 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2962625 | 0.87 | OPRM1 (0.65) | OPRM1OPRD1OPRK1OPRL1MC4R | |
| SCHEMBL3811836 | 0.83 | OPRM1 (0.60) | OPRM1OPRD1OPRK1OPRL1MC4R | |
| SCHEMBL30363975 | 0.83 | OPRM1 (0.61) | OPRM1OPRD1OPRK1OPRL1MC4R | |
| SCHEMBL30364119 | 0.83 | OPRM1 (0.61) | OPRM1OPRD1OPRK1OPRL1MC4R | |
| SCHEMBL1964502 | 0.83 | CYP1A2 (0.62) | OPRM1OPRD1OPRK1OPRL1MC4R | |
| SCHEMBL8916036 | 0.83 | CYP1A2 (0.62) | OPRM1OPRD1OPRK1OPRL1MC4R | |
| SCHEMBL8922757 | 0.81 | CYP1A2 (0.66) | OPRM1OPRD1OPRK1OPRL1MC4R | |
| SCHEMBL4334322 | 0.81 | CYP1A2 (0.66) | OPRM1OPRD1OPRK1OPRL1MC4R | |
| SCHEMBL14593276 | 0.80 | MC4R (0.69) | OPRM1OPRD1OPRK1OPRL1MC4R | |
| SCHEMBL3268419 | 0.79 | SLC6A4 (0.68) | OPRM1OPRD1OPRK1OPRL1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414048-B2 | 4,5-dihydro-isoxazole derivatives and their pharmaceutical use | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-08-19 | — | — | US | disclosed |
| US-6583141-B1 | T cell mediated rheumatic diseases | JANSSEN PHARMACEUTICA, N.V. (BE) | 2003-06-24 | — | — | US | disclosed |