Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL8571326 | 0.80 | HRH1 (0.42) | TAAR1HRH1CA1CA2TSHR | |
| 1-Naphthol SCHEMBL6832333 | 0.79 | CYP1A2 (0.47) | GAATAAR1MAPTHRH1HTR2C | |
| Histamine SCHEMBL4234179 | 0.78 | HRH4 (0.39) | TAAR1LMNAHRH1TSHRSMN1; SMN2 | |
| Histamine SCHEMBL28543874 | 0.78 | HRH4 (0.39) | LMNAHRH1TSHRSMN1; SMN2 | |
| Histamine SCHEMBL28074178 | 0.78 | HRH1 (0.42) | TAAR1LMNAHRH1TSHRSMN1; SMN2 | |
| Histamine SCHEMBL5447892 | 0.78 | — | — | |
| Histamine SCHEMBL289072 | 0.78 | HRH4 (0.42) | LMNAHRH1TSHRSMN1; SMN2 | |
| Histamine SCHEMBL7444650 | 0.78 | HRH4 (0.42) | LMNAHRH1TSHRSMN1; SMN2 | |
| Histamine SCHEMBL1668636 | 0.78 | HRH4 (0.42) | LMNAHRH1TSHRSMN1; SMN2 | |
| Histamine SCHEMBL27340939 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348140-B1 | Clinical indications for genotyping polymorphic variants of G-protein coupled receptors | ACADIA PHARMACEUTICALS, INC. (US) | 2008-03-25 | — | — | US | disclosed |