Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1-Naphthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL3467989 | 0.82 | HRH1 (0.36) | CYP1A2TAAR1ALDH1A1MAPTHRH1 | |
| Histamine SCHEMBL8571326 | 0.79 | HRH1 (0.42) | TAAR1ALDH1A1KDM4EHRH1HTR1B | |
| Histamine SCHEMBL4800524 | 0.79 | GAA (0.38) | TAAR1ALDH1A1KDM4EGAAMAPT | |
| Histamine SCHEMBL28074178 | 0.77 | HRH1 (0.42) | TAAR1HRH1HTR1BCYP2A6HTR2A | |
| Histamine SCHEMBL4234179 | 0.77 | HRH4 (0.39) | TAAR1HRH1CYP2A6HTR2ATSHR | |
| Histamine SCHEMBL28543874 | 0.77 | HRH4 (0.39) | HRH1TSHR | |
| Histamine SCHEMBL7444650 | 0.76 | HRH4 (0.42) | HRH1TSHR | |
| Histamine SCHEMBL1668636 | 0.76 | HRH4 (0.42) | HRH1TSHR | |
| Histamine SCHEMBL5447892 | 0.76 | — | — | |
| Histamine SCHEMBL289072 | 0.76 | HRH4 (0.42) | HRH1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040200902-A1 | Method for marking an information label on a product | FUJI PHOTO FILM CO., LTD. | 2004-10-14 | — | — | US | disclosed |